Relationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B: A meta-analysis
| Autor: | Yong Deng, Weiqiong Zeng, Juan Kang, Qing Luo, Shan Zhong, Feifei Cheng, Da-zhi Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Organophosphonates Renal function Subgroup analysis Kidney Gastroenterology Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hepatitis B Chronic Risk Factors Diabetes mellitus Internal medicine medicine Adefovir Humans Intensive care medicine chronic hepatitis B therapy Creatinine business.industry Adenine renal function General Medicine Odds ratio medicine.disease Newcastle–Ottawa scale meta-analysis chemistry 030220 oncology & carcinogenesis adefovir dipivoxil ComputingMethodologies_DOCUMENTANDTEXTPROCESSING 030211 gastroenterology & hepatology Kidney Diseases business Systematic Review and Meta-Analysis medicine.drug Glomerular Filtration Rate Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text Background: To assess the relationship between adefovir dipivoxil and renal function after anti-hepatitis B virus therapy and elucidate the risk factors involved. Methods: Based on the requirements of the Cochrane systematic review methodology, 21 observational articles on adefovir dipivoxil-associated renal dysfunction were obtained by searching various databases, between January 1, 1995 and July 1, 2016. The Newcastle Ottawa Scale was used to evaluate risk bias. Parameters for 4276 chronic hepatitis B patients were analyzed by Review Manager and R software, and glomerular filtration rate, creatinine clearance, and serum creatinine values were extracted to evaluate renal function. Results: Renal dysfunction was more likely to occur in patients receiving the adefovir dipivoxil therapy (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.40–2.80) than the none-adefovir dipivoxil group. Subgroup analysis showed that renal function predictive value is higher for glomerular filtration rate (OR 2.42, 95% CI 1.34–3.14), compared with serum creatinine levels (OR 1.51, 95% CI 0.75–3.04). The rate of adefovir dipivoxil-associated renal dysfunction was 12% (95% CI 0.08–0.16). Older patients and patients with renal insufficiency, hypertension, and diabetes mellitus were more prone to developing adefovir dipivoxil-associated renal dysfunction; however, integrated raw data were insufficient for further detailed analysis. Conclusion: Long-term adefovir dipivoxil therapy is connected to renal dysfunction in chronic hepatitis B, necessitating the monitoring of kidney function. |
| Databáze: | OpenAIRE |
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