The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance
| Autor: | Ui Soon Jang, Hye-Ra Lee, Chan Woo Kim, Yeongjun Kim, Sandrine M. Soh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
medicine.disease_cause Monoclonal antibody Applied Microbiology and Biotechnology Microbiology TMPRSS2 Neutralization vaccine medicine Humans Receptor Serine protease Mutation variants biology Transmission (medicine) SARS-CoV-2 transmission COVID-19 General Medicine neutralization Virus Internalization Vaccine efficacy Virology Spike Glycoprotein Coronavirus biology.protein Minireview monoclonal antibodies |
| Zdroj: | Journal of Microbiology (Seoul, Korea) |
| ISSN: | 1976-3794 1225-8873 |
| Popis: | The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Some mutated strains are becoming dominant in various parts of the globe because of increased transmissibility as well as cell entry efficacy. Remarkably, the neutralizing activity of monoclonal antibodies, convalescent sera, and vaccines against the variants has been reported to be significantly reduced. Therefore, the efficacy of various monoclonal antibodies therapy and vaccines against these variants is becoming a great global concern. We herein summarize the current status of SARS-CoV-2 with gears shifted towards the recent and most common genetic variants in relation to transmission, neutralizing activity, and vaccine efficacy. |
| Databáze: | OpenAIRE |
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