Recombinant human osteogenic protein 1 in the rat mandibular augmentation model: differences in morphology of the newly formed bone are dependent on the type of carrier
| Autor: | D. C. Rueger, St. Vogeler, Søren Jepsen, M. Tucker, Hendrik Terheyden |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Bone Morphogenetic Protein 7 Bone morphogenetic protein 8A Bone healing Mandible Bone morphogenetic protein Masseter muscle Osseointegration Osteogenesis Transforming Growth Factor beta Bone cell Medicine Animals Humans Rats Wistar Drug Carriers business.industry Anatomy Recombinant Proteins Cell biology Rats Bone morphogenetic protein 7 Bone morphogenetic protein 6 Bone morphogenetic protein 5 Otorhinolaryngology Bone Morphogenetic Proteins Bone Substitutes Surgery Oral Surgery business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1432-9417 |
| Popis: | Recombinant human osteogenic protein 1 (rhOP1), also known as bone morphogenetic protein 7, was investigaed in a newly developed experimental model, the rat lateral mandibular augmentation model. Algipore and Bio-Oss Block were applied as carrier materials. Extensive induction of newly formed bone was demonstrated on the test side containing rhOP1 and did not occur on the control side without rhOP1. The interstitial bone formation was limited to the augmented area and weas not observed in the surrounding masseter muscle. The morphology of the newly formed bone differed in both carrier systems, which may be an important characteristic for the clinical indication of carrier systems in combination with bone morphogenetic proteins. |
| Databáze: | OpenAIRE |
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