Immune and Neuroendocrine Correlates of Temperament in Infancy
| Autor: | Kristin Scheible, Megan R. Gunnar, Jan A. Moynihan, Jennifer Carnahan, Michelle Gilchrist, Thomas G. O'Connor, Ana Vallejo Sefair, Mary T. Caserta, Marcia A. Winter, Claire Wyman, Emma Robertson Blackmore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Longitudinal study Biological correlates Hydrocortisone media_common.quotation_subject Physiology Infant temperament Article Developmental psychology 03 medical and health sciences 0302 clinical medicine Immune system Developmental and Educational Psychology Humans 0501 psychology and cognitive sciences Longitudinal Studies Saliva Temperament media_common Innate immune system Venipuncture 05 social sciences Infant Psychiatry and Mental health Cytokines Observational study Female Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Popis: | There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|