High-frequency power within the QRS complex in ischemic cardiomyopathy patients with ventricular arrhythmias: Insights from a clinical study and computer simulation of cardiac fibrous tissue
| Autor: | Daisuke Wakatsuki, Toshiaki Nakajima, Takeshi Tsutsumi, Nami Takano, Yoshiwo Okamoto, Takanobu Tomaru |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Myocardial Ischemia Health Informatics Fibrous tissue 030204 cardiovascular system & hematology Clinical study 03 medical and health sciences QRS complex Electrocardiography 0302 clinical medicine Internal medicine medicine Humans In patient Computer Simulation Aged Aged 80 and over Ischemic cardiomyopathy High frequency power Fourier Analysis business.industry Arrhythmias Cardiac Reentry Middle Aged Computer Science Applications 030104 developmental biology Cardiology Female business |
| Zdroj: | Computers in biology and medicine. 87 |
| ISSN: | 1879-0534 |
| Popis: | Background The distribution of frequency power (DFP) within the QRS complex (QRS) is unclear. This study aimed to investigate the DFP within the QRS in ischemic cardiomyopathy (ICM) with lethal ventricular arrhythmias (L-VA). A computer simulation was performed to explore the mechanism of abnormal frequency power. Methods The study included 31 ICM patients with and without L-VA (n = 10 and 21, respectively). We applied the continuous wavelet transform to measure the time-frequency power within the QRS. Integrated time-frequency power (ITFP) was measured within the frequency range of 5–300 Hz. The simulation model consisted of two-dimensional myocardial tissues intermingled with fibroblasts. We examined the relation between frequency power calculated from the simulated QRS and the fibroblast-to-myocyte ratio (r) of the model. Results The frequency powers significantly increased from 180 to 300 Hz and from 5 to 15 Hz, and also decreased from 45 to 80 Hz in patients with ICM and L-VA compared with the normal individuals. They increased from 110 Hz to 250 Hz in ICM alone. In the simulation, the high-frequency power increased when the ratio (r) were 2.0–2.5. Functional reentry was initiated if the ratio (r) increased to 2.0. Conclusions Abnormal higher-frequency power (180–300 Hz) may provide arrhythmogenic signals in ICM with L-VA that may be associated with the fibrous tissue proliferation. |
| Databáze: | OpenAIRE |
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