Late-onset acute disseminated encephalomyelitis followed by optic neuritis without anti-myelin oligodendrocyte glycoprotein antibodies: a biopsied case report
| Autor: | Makoto Mori, Toshiyuki Takahashi, Ichiro Nozaki, Yuta Usui, Yasutake Tada, Kenji Sakai, Toshiya Ichinose, Mitsutoshi Nakada, Shingo Tanaka, Masahito Yamada |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pathology Optic Neuritis Neurology Biopsy Late onset Dermatology Myelin oligodendrocyte glycoprotein 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans Optic neuritis 030212 general & internal medicine Pathological Aged Autoantibodies medicine.diagnostic_test biology business.industry Brain biopsy Encephalomyelitis Acute Disseminated General Medicine medicine.disease Oligodendrocyte Psychiatry and Mental health medicine.anatomical_structure Acute disseminated encephalomyelitis biology.protein Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurological Sciences. 42:4731-4735 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | Background Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ADEM-ON) is characterized by the following features: early onset, monophasic or multiphasic ADEM followed by one or more episodes of ON, and the presence of serum anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. Case report We report a case of ADEM-ON without anti-MOG antibodies in a 78-year-old woman. The patient developed acute-onset neurological findings and was diagnosed with ADEM. She was treated with intravenous methylprednisolone (IVMP), and oral corticosteroids. Her clinical symptoms and MRI findings subsequently improved. Left optic neuritis emerged 6 months later, and we made a diagnosis of ADEM-ON. A brain biopsy performed during the acute phase of ADEM showed perivascular infiltration of macrophages with demyelination. Conclusion The majority of the reported ADEM-ON cases are pediatric cases with serum anti-MOG antibodies, but our patient was the elderly, without anti-MOG antibodies. Moreover, the pathological features of our case were similar to those observed in patients with typical ADEM and in patients with anti-MOG antibody-positive ADEM. Although ADEM-ON is related to the presence of anti-MOG antibodies, factors other than anti-MOG antibodies could contribute to the development of ADEM-ON. |
| Databáze: | OpenAIRE |
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