The basal nutritional state of PDAC patients is the dominant factor for completing adjuvant chemotherapy
| Autor: | Koichi Kawamoto, Takehiro Noda, Kunihito Gotoh, Hideo Tomihara, Hidetoshi Eguchi, Masahiro Tanemura, Hiroshi Wada, Yutaka Takeda, Yuichiro Doki, Masaki Mori, Daisaku Yamada, Tadafumi Asaoka |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Oncology medicine.medical_specialty Multivariate analysis Adjuvant chemotherapy medicine.medical_treatment Nutritional Status 03 medical and health sciences Basal (phylogenetics) Pancreatectomy 0302 clinical medicine Surgical oncology Internal medicine Preoperative Care medicine Humans Aged Retrospective Studies Chemotherapy Receiver operating characteristic business.industry Age Factors General Medicine Odds ratio Middle Aged Prognosis Pancreatic Neoplasms Clinical trial Nutrition Assessment ROC Curve Chemotherapy Adjuvant 030220 oncology & carcinogenesis Multivariate Analysis Female 030211 gastroenterology & hepatology Surgery Nutrition Therapy business Carcinoma Pancreatic Ductal Follow-Up Studies |
| Zdroj: | Surgery Today. 47:1361-1371 |
| ISSN: | 1436-2813 0941-1291 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, and several clinical trials have shown that adjuvant chemotherapy after curative resection can improve the prognosis of these patients. However, the adjuvant chemotherapy completion rate is less than satisfactory. If this rate could be increased then the overall prognosis of PDAC might be improved; however, reports addressing this problem are insufficient. To elucidate the factors, we retrospectively investigated PDAC patients. Various factors of 121 PDAC patients undergoing R0 resection, including preoperatively treated patients, were investigated. Univariate and multivariate analyses were performed to investigate the factors that were associated with the completion of adjuvant chemotherapy. The analysis identified age and the prognostic nutritional index (PNI) as significant independent factors. A receiver operating characteristic curve analysis of age yielded a cutoff value of 67 years (sensitivity, 64%; specificity, 78%). Univariate and multivariate analyses of the 61 patients who were over 67 years of age revealed that the PNI (odds ratio, 0.85; P = 0.048) and Evans grade (odds ratio, 0.041; P = 0.0010) were significant factors for the completion of chemotherapy. The results of our investigation suggest that nutrition should be controlled in older PDAC patients to facilitate the completion of adjuvant chemotherapy. |
| Databáze: | OpenAIRE |
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