Oesophageal ulceration in adult patients treated with doxycycline for acne vulgaris
| Autor: | Chun-Xia Li, Wei-Qin Zhu, Hua-Ming Li, Ya-Hong He, Yu-Fang Wang, Yan Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oesophageal ulceration
Adult Male medicine.medical_specialty Medicine (General) Case Reports Esophageal Diseases Biochemistry Young Adult R5-920 Oesophageal injury Acne Vulgaris Humans Medicine OESOPHAGEAL ULCERATION Ulcer Acne Doxycycline doxycycline medicine.diagnostic_test Adult patients business.industry Biochemistry (medical) Endoscopy Cell Biology General Medicine Oesophageal diseases oesophageal diseases medicine.disease Dermatology Female oesophageal injury business medicine.drug |
| Zdroj: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objective To report drug-induced oesophageal ulceration in adult patients treated with doxycycline for acne vulgaris. Methods This retrospective case series included data from adult patients treated with oral doxycycline therapy for acne vulgaris, who had presented with oesophageal ulceration at the Third People’s Hospital of Hangzhou between June 2016 and December 2017, and whose diagnosis was confirmed by gastroscopy. Clinicodemographic data were analysed, including symptom onset, endoscopy results, that were assessed for classic features of oesophageal ulceration. Patients were questioned regarding medication intake. Results A total of 12 patients were included (mean age, 23.50 ± 3.20 years), eight (66.67%) of whom were female. Based on history of medication and endoscopic findings, these patients were diagnosed with doxycycline-induced oesophageal ulceration. Most patients were found to have taken the medication at bedtime, just before lying down, and/or with insufficient water. Conclusion Doxycycline may cause oesophageal irritation when not taken with sufficient water, or taken just before lying down to sleep. Prescribing physicians should be aware of these issues, and instruct patients as to the correct method for intake of doxycycline. |
| Databáze: | OpenAIRE |
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