COL5A2 as a potential clinical biomarker for gastric cancer and renal metastasis
| Autor: | Shu-Fang Sun, Guang-Liang Zhao, Yun-Long Ding |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent overall survival renal metastasis Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms Internal medicine Biomarkers Tumor Medicine Humans 030212 general & internal medicine Risk factor Pathological collagen type V alpha2 chain Aged Aged 80 and over Receiver operating characteristic business.industry Proportional hazards model gastric cancer Area under the curve Univariate Cancer General Medicine Clinical Trial/Experimental Study Middle Aged medicine.disease Kidney Neoplasms pathologic grade 030220 oncology & carcinogenesis Female business Collagen Type V Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Gastric cancer, characterized by insidious onset and multiple metastasis, is almost incurable and has poor prognosis, and also one of the leading causes of treatment failure and death in patients with gastric cancer (GC). However, the prognosis of collagen type V alpha2 chain (COL5A2) in GC and renal metastasis is unknown. Methods: Recruited 148 patients who underwent GC. The diagnosis of GC was confirmed by ultrasound imaging and pathological examination. Immunohistochemistry and RT-qPCR were performed to exam the expression level of COL5A2. The statistical methods included Pearson chi-square test, Spearman-rho correlation test, univariate and multivariate cox regression analysis. Finally, this research constructed receiver operating characteristic (ROC) curves and applied the area under the curve (AUC). Results: Based on Pearson's chi-square test, Spearman-rho test, and univariate/multivariate cox regression, pathologic grade (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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