Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
| Autor: | Yu Min Huang, Kuo Yi Yang, Chih-Yu Chen, Chien Cheng Tai, Hon Lok Lo, Shin I. Huang, Pei I. Tsai, Yen Hua Huang, Tzu Hung Lin, Chen Kun Liaw, Wen Chih Liu, Huang Chih Chieh, Jui Sheng Sun, Hsin Hsin Shen, Chun Kuan Lu |
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| Rok vydání: | 2021 |
| Předmět: |
Calcium Phosphates
suture anchor Polymers Scanning electron microscope Biocompatible Materials 02 engineering and technology Blood Urea Nitrogen Random Allocation 0302 clinical medicine Absorbable Implants Materials Testing Femur Biology (General) Spectroscopy Suture anchors chemistry.chemical_classification Molecular Structure Alanine Transaminase Equipment Design General Medicine Polymer 021001 nanoscience & nanotechnology Biomechanical Phenomena Computer Science Applications Chemistry Creatinine iron-based Rabbits 0210 nano-technology Porosity Materials science Biocompatibility QH301-705.5 Iron additive manufacturing (3D printing) Calcium Sulfate Article Catalysis Inorganic Chemistry 03 medical and health sciences Osseointegration Suture Anchors Tensile Strength Animals MTT assay Physical and Theoretical Chemistry QD1-999 Molecular Biology Lasers Organic Chemistry X-Ray Microtomography 030229 sport sciences bioabsorbable Viscera chemistry Iron based Helix Microscopy Electron Scanning Nuclear chemistry |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 14 International Journal of Molecular Sciences, Vol 22, Iss 7368, p 7368 (2021) |
| ISSN: | 1422-0067 |
| Popis: | This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development. |
| Databáze: | OpenAIRE |
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