Vascularization of the human intervertebral disc: A scoping review
| Autor: | Patti K. Kiser, J. Kevin Shoemaker, Michele C. Battié, Dale E. Fournier, Cheryle A. Séguin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
intervertebral disk vasculature Web of science MEDLINE Dentistry Reviews Review anulus fibrosus 03 medical and health sciences 0302 clinical medicine blood vessel Medicine annulus fibrosus Orthopedics and Sports Medicine 10. No inequality 030304 developmental biology 0303 health sciences business.industry Cartilage nucleus pulposus vascularisation Intervertebral disc cartilage endplate musculoskeletal system blood supply 3. Good health Intervertebral disk Dissection medicine.anatomical_structure Systematic review Blood supply intervertebral disc business 030217 neurology & neurosurgery |
| Zdroj: | Paediatrics Publications JOR Spine |
| Popis: | Intervertebral discs (IVDs) are often referred to as the largest avascular structures of the human body, yet a collective resource characterizing the vascularization of the IVD does not exist. To address this gap, the objective of this study was to conduct a comprehensive search of the literature to review and summarize current knowledge of the prevalence and localization of blood supply in human IVDs, with a scoping review. A comprehensive search of peer‐reviewed publications on the topic of IVD vascularization in humans was conducted across six electronic databases: PubMed, EMBASE, MEDLINE, Scopus, Web of Science, and BIOSIS Previews. Studies of humans were included regardless of age, sex, ethnicity, and health status, with the exception of IVD herniation. Two independent reviewers screened titles and abstracts and full‐texts according to eligibility criteria. The review was conducted and reported according to Preferred Reporting Items for Systematic Reviews Extension for Scoping Reviews guidelines. Our search yielded 3122 articles, with 22 articles meeting the inclusion criteria. The study samples ranged in age from fetal to >90 years and included both sexes, various health statuses, and used different methodologies (eg, histology, medical imaging, and gross dissection) to assess vasculature. Overall, consistent observations were that (a) the nucleus pulposus of the IVD is avascular throughout life, (b) both the cartilage endplates and annulus fibrosus receive considerable blood supply early in life that diminishes over the lifespan, and (c) vascular ingrowth into the cartilage endplates and inner layers of the annulus fibrosus is commonly associated with damaged or disrupted tissue, irrespective of age. Histology and immunohistochemistry are often used to report vascularization of the IVD. The body of the current literature suggests that the IVD should not be generalized as an avascular tissue. Instead, vascularization of the IVD differs based on the constituent tissues, their age, and state of degeneration or damage. |
| Databáze: | OpenAIRE |
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