Metabolic profiling of Escherichia coli by ion mobility-mass spectrometry with MALDI ion source
| Autor: | Denis Langlais, Amina S. Woods, Shelley N. Jackson, Luying Xun, Prabha Dwivedi, Herbert H. Hill, William F. Siems, Geoffery Puzon, Albert J. Schultz, Kimberly Kaplan, Maggie Tam |
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| Rok vydání: | 2010 |
| Předmět: |
Ions
MALDI imaging Spectrometry Mass Electrospray Ionization Chromatography Protein mass spectrometry Chemistry Ion-mobility spectrometry Electrospray ionization Analytical chemistry Mass spectrometry Article Ion source Matrix-assisted laser desorption/ionization Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Escherichia coli Metabolome Mass spectrum Metabolomics Spectroscopy |
| Zdroj: | Journal of Mass Spectrometry. 45:1383-1393 |
| ISSN: | 1076-5174 |
| Popis: | Comprehensive metabolome analysis using mass spectrometry (MS) often results in a complex mass spectrum and difficult data analysis resulting from the signals of numerous small molecules in the metabolome. In addition, MS alone has difficulty measuring isobars and chiral, conformational and structural isomers. When a matrix-assisted laser desorption ionization (MALDI) source is added, the difficulty and complexity are further increased. Signal interference between analyte signals and matrix ion signals produced by MALDI in the low mass region ( |
| Databáze: | OpenAIRE |
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