Obesity-related metabolite profiles of black women spanning the epidemiologic transition
Autor: | Elin Chorell, Lara R. Dugas, Guichan Cao, Amy Luke, Richard S. Cooper, Tommy Olsson, Jacob Plange-Rhule, Brian T. Layden, Denise Scholten, Estelle V. Lambert, Julia H. Goedecke |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Metabolite Clinical Biochemistry 030209 endocrinology & metabolism Type 2 diabetes Biology Biochemistry Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Palmitoleic acid chemistry.chemical_classification medicine.disease Obesity Amino acid 030104 developmental biology Endocrinology chemistry Uric acid Arachidonic acid Mannitol medicine.drug |
Zdroj: | Metabolomics : Official journal of the Metabolomic Society. 12(3) |
ISSN: | 1573-3882 |
Popis: | In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity. |
Databáze: | OpenAIRE |
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