Contribution to the determination of the chemotherapeutic drug G1 in biological fluids
| Autor: | Francisco Ramos, Daniel Gebru W, Rolando Tápanes Peraza, Michael, Jorge Pérez Ávila, Alina Martínez Rodríguez, Lizette Gil del Valle |
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| Rok vydání: | 1997 |
| Předmět: |
Drug
Internal standard Antifungal Agents Chromatography Gas Chromatography Chemistry media_common.quotation_subject Extraction (chemistry) Antifungal drug Antineoplastic Agents General Chemistry Nitro Compounds Anti-Infective Agents Pharmacokinetics Gas chromatography Furans Quantitative analysis (chemistry) media_common Antibacterial agent |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 698:312-316 |
| ISSN: | 0378-4347 |
| Popis: | A sensitive gas chromatographic method for the quantitative determination of the new antibacterial and antifungal drug G1, 1-(5-bromofuran-2-yl)-2-bromo-2-nitroethene, has been optimized. The method involves a fast and single extraction step from spiked serum and urine samples. The G1 drug was quantified using an internal standard method and by means of a nitrogen-selective detector. The results are statistically significant and show that mean levels of G1 as low as 1 μg ml −1 can be measured accurately. |
| Databáze: | OpenAIRE |
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