Serum lipoprotein-associated phospholipase A2 as a promising prognostic biomarker in association with 90-day outcome of acute intracerebral hemorrhage
| Autor: | Lian-Gang Mao, Yi Sun, Lin Bian, Feng Shen, Wei Zhou, Jun-Feng Chen, Zheng Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Multivariate analysis Clinical Biochemistry Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Hematoma Modified Rankin Scale Internal medicine medicine Humans Prognostic biomarker cardiovascular diseases Aged Cerebral Hemorrhage Intracerebral hemorrhage business.industry Lipoprotein-associated phospholipase A2 Biochemistry (medical) General Medicine Middle Aged Prognosis medicine.disease Pathophysiology nervous system diseases 030104 developmental biology 030220 oncology & carcinogenesis 1-Alkyl-2-acetylglycerophosphocholine Esterase Acute Disease Biomarker (medicine) Female lipids (amino acids peptides and proteins) business Biomarkers |
| Zdroj: | Clinica Chimica Acta. 495:429-435 |
| ISSN: | 0009-8981 |
| Popis: | Lipoprotein-associated phospholipase A2 (Lp-PLA2) is reflective of vascular inflammation and plays a role in the pathophysiology of cerebrovascular disease. We determine usefulness of serum Lp-PLA2 as a prognostic biomarker for intracerebral hemorrhage (ICH).In this prospective, observational study, serum Lp-PLA2 concentrations were detected among 164 patients with acute spontaneous basal ganglia hemorrhage and 164 healthy controls. Using multivariate analysis, we analyzed its association with poor outcome (modified Rankin Scale2) at poststroke 90 days and hemorrhagic severity indicated by National Institutes of Health Stroke Scale (NIHSS) score and hematoma volume.Serum Lp-PLA2 concentrations were remarkably higher in patients than in controls. Lp-PLA2 concentrations were independently correlated with NIHSS score (t = 5.095, P .001) and hematoma volume (t = 2.850, P = .005). At 90-day follow-up, 85 patients (51.8%) had poor outcome. Under receiver operating characteristic curve, serum Lp-PLA2 showed a significant prognostic discriminatory capability (AUC, 0.813; 95% CI, 0.744-0.869). Serum Lp-PLA2 concentrations ≥304 ng/ml was an independent predictor associated with poor outcome (OR 7.052; 95% CI 1.971-25.228).Rising serum Lp-PLA2 concentrations are closely hemorrhagic severity and clinical outcomes after ICH, substantializing serum Lp-PLA2 as a potential prognostic biomarker of ICH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect