Axonal damage in the optic radiation assessed by white matter tract integrity metrics is associated with retinal thinning in multiple sclerosis
| Autor: | Maya N. Polackal, Qiuyun Fan, Thomas Witzel, Andrew W. Russo, Natalya Machado, Ilena C. George, Chanon Ngamsombat, Susie Y. Huang, Eric C. Klawiter, Qiyuan Tian |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Visual acuity genetic structures Nerve fiber layer lcsh:RC346-429 chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Diffusion tractography 05 social sciences Retinal thinning Regular Article Middle Aged White Matter medicine.anatomical_structure Diffusion Tensor Imaging Neurology lcsh:R858-859.7 Female medicine.symptom Adult medicine.medical_specialty Multiple Sclerosis Optic Neuritis Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology Retina White matter 03 medical and health sciences Young Adult Ophthalmology medicine Optic radiation Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Optic neuritis Visual Pathways lcsh:Neurology. Diseases of the nervous system Aged Optical coherence tomography business.industry Retinal medicine.disease eye diseases Axons White matter tract integrity Diffusion Magnetic Resonance Imaging chemistry Neurology (clinical) sense organs business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 27, Iss, Pp 102293-(2020) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Optic radiation (OR) white matter damage is associated with retinal thinning in MS. • Axonal water fraction (AWF) reflects axonal damage in the OR of MS patients. • AWF in the OR shows a tract-specific association with retinal thinning. Introduction White matter damage in the visual pathway is common in multiple sclerosis (MS) and is associated with retinal thinning, although the underlying mechanism of association remains unclear. The goal of this work was to evaluate the presence and extent of white matter tract integrity (WMTI) alterations in the optic radiation (OR) in people with MS and to investigate the association between WMTI metrics and retinal thinning in the eyes of MS patients without a history of optic neuritis (ON) as measured by optical coherence tomography (OCT). We hypothesized that WMTI metrics would reflect axonal damage that occurs in the OR in MS, and that axonal alterations revealed by WMTI would be associated with retinal thinning. Methods Twenty-nine MS patients without previous ON in at least one eye and twenty-nine age-matched healthy controls (HC) were scanned on a dedicated high-gradient 3-Tesla MRI scanner with 300 mT/m maximum gradient strength using a multi-shell diffusion MRI protocol (b = 800, 1500, 2400 s/mm2). The patients were divided into two subgroups according to history without ON (N = 18) or with ON in one eye (N = 11). Diffusion tensor imaging (DTI) metrics and WMTI metrics derived from diffusion kurtosis imaging were assessed in normal-appearing white matter (NAWM) of the OR and in focal lesions. Retinal thickness in the eyes of MS patients was measured by OCT. Student’s t-test was used to assess group differences between MRI metrics. Linear regression was used to study the relationship between OCT metrics, including retinal nerve fiber layer (RNFL) and combined ganglion cell and inner plexiform layer thickness (GCL/IPL), visual acuity measures and DTI and WMTI metrics. Results OR NAWM in MS showed significantly decreased axonal water fraction (AWF) compared to HC (0.36 vs 0.39, p |
| Databáze: | OpenAIRE |
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