Spontaneous fundus lesions in elderly monkeys: An ideal model for age-related macular degeneration and high myopia clinical research
| Autor: | Baozhu Zeng, Weihua Li, Hening Zhang, Bing Huang, Yanming Chen, Wang Zhang, Zhiquan Li, Peixin Wu, Huan Yu, Yuting Peng, Yaojue Xie, Xing Liu, Sujuan Qiu, Yanwei Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Fundus Oculi Drusen Fundus (eye) General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Macular Degeneration Ophthalmology Myopia Medicine Animals General Pharmacology Toxicology and Pharmaceutics Fluorescein Angiography Pathological Retinoscopy medicine.diagnostic_test business.industry Retinal General Medicine Macular degeneration medicine.disease eye diseases Disease Models Animal Macaca fascicularis Choroidal neovascularization Clinical research chemistry Female sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Life sciences. 282 |
| ISSN: | 1879-0631 |
| Popis: | Aims Age-related macular degeneration (AMD) and high myopia are frequent causes of progressive visual impairment, so it is critical to identify animal models with resembling human retinal physiology, AMD and high myopia pathological features for therapeutic studies. Main methods We screened elderly cynomolgus monkeys for fundus lesions by slit-lamp biomicroscope combined with fundus pre-set lens and further examined positive cases by color fundus photography (CFP), optical coherence tomography (OCT), fundus fluorescein angiography (FFA), streak retinoscopy, and A-scan ultrasonography. Key findings Among the 156 animals examined, 10 males and 5 females (30 eyes) exhibited fundus abnormalities (9.6% prevalence). Multi-modal imaging revealed drusen in 20 eyes of 11 animals (prevalence rate of 7.1%), tessellated fundus in 22 eyes of 11 animals, and myopia choroidal neovascularization (CNV) in 4 eyes of 3 animals. Significance Aged cynomolgus monkeys exhibit spontaneous fundus lesions resembling human AMD and high myopia, which could be an ideal model for clinical research. |
| Databáze: | OpenAIRE |
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