Polycythemia in rats following restricted food intake
| Autor: | Herbert Wohl, Clarence Merskey |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Food intake Erythrocytes media_common.quotation_subject Polycythemia Hematocrit Body weight Hemoglobins Blood serum Physiology (medical) Internal medicine Blood plasma Leukocytes medicine media_common medicine.diagnostic_test Red Cell Chemistry Research Body Weight Appetite Diet Rats Endocrinology Hemoglobin |
| Zdroj: | American Journal of Physiology-Legacy Content. 206:762-764 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1964.206.4.762 |
| Popis: | Rats were divided into two groups such that mean weight and hemoglobin and hematocrit levels were not significantly different. One group (controls) was then fed a normal chow ad libitum. The other group was fed 6 g daily (30% of normal intake) for 2 weeks. The hemoglobin levels of rats fed the restricted diet rose 1.4–3.5 g/100 ml and hematocrit level rose 2–6%. At the end of 2 weeks total red cell mass (Cr51) was 5.5–6.0 ml in the underfed groups compared with 6.8 ml in the control group. Body weight fell proportionally more than did red cell mass, elevating the calculated red cell mass per unit body weight. Serum osmolality and K+ were not significantly different from control values, and there was a slightly higher serum Na+ and Cl– in the restricted diet group. It is concluded that restriction of food intake produced a relative polycythemia. At the end of 2 weeks of restriction an isosmotic reduction in plasma volume was present. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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