A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum
| Autor: | Kyo Noguchi, Atsushi Furuichi, Shi-Yu Zhou, Masayoshi Kurachi, Michio Suzuki, Yasuhiro Kawasaki, Kazue Nakamura, Hikaru Seto, Tsutomu Takahashi, Ryoichiro Tanino, Mikio Kido |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Audiology behavioral disciplines and activities Temporal lobe Superior temporal gyrus medicine Image Processing Computer-Assisted Humans Longitudinal Studies Psychiatry Biological Psychiatry Pharmacology First episode Fusiform gyrus medicine.diagnostic_test Magnetic resonance imaging Organ Size medicine.disease Magnetic Resonance Imaging Temporal Lobe nervous system Schizophrenia Female Atrophy Psychology Schizophrenia spectrum Follow-Up Studies |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 35(8) |
| ISSN: | 1878-4216 |
| Popis: | While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the superior temporal gyrus (STG) during the early phases of schizophrenia, it remains largely unknown whether other temporal lobe structures also exhibit similar progressive changes and whether these changes, if present, are specific to schizophrenia among the spectrum disorders. In this longitudinal MRI study, the gray matter volumes of the fusiform, middle temporal, and inferior temporal gyri were measured at baseline and follow-up scans (mean inter-scan interval=2.7 years) in 18 patients with first-episode schizophrenia, 13 patients with schizotypal disorder, and 20 healthy controls. Both schizophrenia and schizotypal patients had a smaller fusiform gyrus than controls bilaterally at both time points, whereas no group difference was found in the middle and inferior temporal gyri. In the longitudinal comparison, the schizophrenia patients showed significant fusiform gyrus reduction (left, -2.6%/year; right, -2.3%/year) compared with schizotypal patients (left: -0.4%/year; right: -0.2%/year) and controls (left: 0.1%/year; right: 0.0%/year). However, the middle and inferior temporal gyri did not exhibit significant progressive gray matter change in all diagnostic groups. In the schizophrenia patients, a higher cumulative dose of antipsychotics during follow-up was significantly correlated with less severe gray matter reduction in the left fusiform gyrus. The annual gray matter loss of the fusiform gyrus did not correlate with that of the STG previously reported in the same subjects. Our findings suggest regional specificity of the progressive gray matter reduction in the temporal lobe structures, which might be specific to overt schizophrenia within the schizophrenia spectrum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect