Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys
| Autor: | Francis K.-Y. Pau, R.J. Chang, W.K. McGee, J. L. Cameron, Richard L. Stouffer, C. R. Pohl, Cecily V. Bishop, John C. Marshall |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Aging Physiology Endocrinology Diabetes and Metabolism media_common.quotation_subject Ovary Enzyme-Linked Immunosorbent Assay Luteal phase Biology Motor Activity Diet High-Fat Gonadotropin-Releasing Hormone Absorptiometry Photon Physiology (medical) Internal medicine Follicular phase medicine Animals Testosterone Ovarian follicle Menstrual cycle media_common Adiposity Drug Implants Reproduction Body Weight Articles Glucose Tolerance Test Luteinizing Hormone Antral follicle Polycystic ovary Macaca mulatta Neurosecretory Systems medicine.anatomical_structure Endocrinology Cholesterol Metabolism Female Luteinizing hormone Hyperandrogenism |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 306(11) |
| ISSN: | 1522-1555 |
| Popis: | Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants ( n = 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to the reproductive axis [increased luteinizing hormone (LH) pulse frequency] at 5 yr, without remarkable changes in ovarian or metabolic features. To examine the combined effects of T and obesity, at 5.5 yr (human equivalent age: 17 yr), monkeys were placed on a high-calorie, high-fat diet typical of Western cultures [Western style diet (WSD)], which increased body fat from |
| Databáze: | OpenAIRE |
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