Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
| Autor: | Renée T. Fortner, Fulvio Ricceri, Guri Skeie, Eva Lundin, Pagona Lagiou, Kay-Tee Khaw, Antonia Trichopoulou, Elio Riboli, Krasimira Aleksandrova, Kim Overvad, Annika Idahl, Piet A. van den Brandt, Konstantinos K. Tsilidis, Louise Hansen, Rosario Tumino, Elisabete Weiderpass, Mireia Obón-Santacana, N. Charlotte Onland-Moret, Pietro Ferrari, José María Huerta, H. Bas Bueno-de-Mesquita, Saioa Chamosa, Petra H.M. Peeters, Heiner Boeing, Domenico Palli, María José Sánchez, Marc J. Gunter, Emily Sonestedt, Ioanna Tzoulaki, Mie Jareid, Melissa A. Merritt, J. Ramón Quirós, Rudolf Kaaks, Chirag J. Patel, Joana Alves Dias, Mathilde His, Leo J. Schouten, Vittorio Krogh, Anne Tjønneland, Christina Bamia, Laureen Dartois, Nicholas J. Wareham, Aurelio Barricarte, Amalia Mattiello, Marie-Christine Boutron-Ruault, Ruth C. Travis |
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| Přispěvatelé: | University Medical Center Utrecht, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Oncology saturated fat endocrine system diseases Saturated fat Medicine (miscellaneous) Carcinoma Ovarian Epithelial 09 Engineering Cohort Studies 0302 clinical medicine Nutrient Risk Factors Ovarian Epithelial Neoplasms Neoplasms Glandular and Epithelial 030212 general & internal medicine Non-U.S. Gov't Prospective cohort study Netherlands RISK Ovarian Neoplasms Nutrition and Dietetics Research Support Non-U.S. Gov't Fatty Acids Glandular and Epithelial 11 Medical And Health Sciences Middle Aged female genital diseases and pregnancy complications European Prospective Investigation into Cancer and Nutrition Original Research Communications nutrition ovarian cancer 030220 oncology & carcinogenesis Meta-analysis Female HEALTH Life Sciences & Biomedicine Cohort study Adult medicine.medical_specialty QUESTIONNAIRE prospective cohort DIETARY-FAT INTAKE Research Support N.I.H POOLED ANALYSIS 03 medical and health sciences Breast cancer Research Support N.I.H. Extramural Internal medicine Journal Article medicine BREAST-CANCER Humans Aged Gynecology Science & Technology Nutrition & Dietetics business.industry Carcinoma SCALE PROSPECTIVE COHORT Extramural Feeding Behavior medicine.disease Dietary Fats Diet serous Nutrition Ovarian cancer Prospective cohort Serous business diet Meta-Analysis |
| Zdroj: | American Journal of Clinical Nutrition, 103(1), 161-167. Oxford University Press American Journal of Clinical Nutrition, 103(1), 161. American Society for Nutrition BASE-Bielefeld Academic Search Engine Merritt, M A, Tzoulaki, I, van den Brandt, P A, Schouten, L J, Tsilidis, K K, Weiderpass, E, Patel, C J, Tjønneland, A, Hansen, L, Overvad, K, His, M, Dartois, L, Boutron-Ruault, M-C, Fortner, R T, Kaaks, R, Aleksandrova, K, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Palli, D, Krogh, V, Tumino, R, Ricceri, F, Mattiello, A, Bueno-de-Mesquita, H B, Onland-Moret, N C, Peeters, P H, Skeie, G, Jareid, M, Quirós, J R, Obón-Santacana, M, Sánchez, M-J, Chamosa, S, Huerta, J M, Barricarte, A, Dias, J A, Sonestedt, E, Idahl, A, Lundin, E, Wareham, N J, Khaw, K-T, Travis, R C, Ferrari, P, Riboli, E & Gunter, M J 2016, ' Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study ', The American Journal of Clinical Nutrition, vol. 103, no. 1, pp. 161-7 . https://doi.org/10.3945/ajcn.115.118588 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.115.118588 |
| Popis: | BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.DESIGN: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).CONCLUSION: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat. |
| Databáze: | OpenAIRE |
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