Bioactivation of inert alumina ceramics by hydroxylation
| Autor: | Rainer Telle, Fritz Niethard, Nadine Kaltenborn, Rudolf Marx, Andreas Prange, Christopher Niedhart, Horst Fischer |
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| Rok vydání: | 2005 |
| Předmět: |
Materials science
Biocompatibility Surface Properties Osteocalcin Biophysics Biocompatible Materials Bioengineering Hydroxylation Biomaterials chemistry.chemical_compound Osseointegration Tensile Strength Materials Testing Ultimate tensile strength Aluminum Oxide Cell Adhesion Humans Sodium Hydroxide Ceramic Composite material Cells Cultured Cell Proliferation Osteoblasts Aluminium hydroxide Cell Differentiation Elasticity chemistry Mechanics of Materials Sodium hydroxide visual_art Ceramics and Composites visual_art.visual_art_medium Stress Mechanical Implant Cell activation |
| Zdroj: | Biomaterials. 26:6151-6157 |
| ISSN: | 0142-9612 |
| Popis: | Alumina ceramics (Al(2)O(3)) are frequently used for medical implants and prostheses because of the excellent biocompatibility, and the high mechanical reliability of the material. Inauspiciously alumina is not suitable for implant components with bone contact, because the material is bioinert and thereby no bony ongrowth, and subsequently loosening of the implant occurs. Here, we present a new method to bioactivate the surface of the material. Specimens made of high purity alumina were treated in sodium hydroxide. Cell culture tests with osteoblast-like cells as well as spectroscopical and mechanical tests were performed. Aluminium hydroxide groups were detected on the surface of the treated specimens. Enhanced cell adhesion, proliferation and secretion of osteocalcin were determined after hydroxylation. The bioactivating treatment had no deteriorating effect on the short- and long-term strength behaviour. Our results indicate that the described surface technique could be used to develop a new class of osseointegrative high-strength ceramic implants. |
| Databáze: | OpenAIRE |
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