Major outer membrane proteins from many Campylobacter species cross-react with cholera toxin
| Autor: | M. John Albert, Shilpa Haridas, Ben Adler |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Cholera Toxin Clinical Biochemistry Immunology Campylobacteriosis Biology Cross Reactions medicine.disease_cause Campylobacter jejuni Microbiology Cricetinae medicine Immunology and Allergy Animals Toxin Campylobacter Chinese hamster ovary cell Cholera toxin medicine.disease biology.organism_classification bacterial infections and mycoses Vaccine Research Cholera Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Clinical and vaccine immunology : CVI. 15(5) |
| ISSN: | 1556-679X |
| Popis: | We have previously shown that Campylobacter jejuni strains do not produce a functional cholera toxin-like toxin (CTLT) detectable in a Chinese hamster ovary cell assay. Instead, the 53-kDa major outer membrane protein (OMP) of C. jejuni , PorA, reacts with cholera toxin (CT) antibody on immunoblots. Here, we have extended this observation to other species of Campylobacter , including C. coli, C. lari, C. fetus, C. hyointestinalis , and C. upsaliensis , the common 53-kDa OMP of which reacted with CT antibody in immunoblotting assays. There were additional reactive bands for C. fetus . As with C. jejuni , this finding may lead to the erroneous conclusion that these additional species produce a functional CTLT. However, this common cross-reactive OMP can be explored as a vaccine candidate to prevent campylobacteriosis. |
| Databáze: | OpenAIRE |
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