High expression of leptin receptor leads to temozolomide resistance with exhibiting stem/progenitor cell features in gliobalastoma
| Autor: | xiaohu hu, Guosheng Han, Liu Jianmin, Wen-Yuan Zhao, Yue Zhijian, Lai-xing Wang, Zhao Rui, Xiaoping Zhou, Li Yanan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
STAT3 Transcription Factor
Population Apoptosis SOX2 Antigens CD Report Cell Line Tumor medicine Temozolomide Humans AC133 Antigen Progenitor cell STAT3 education Molecular Biology neoplasms Antineoplastic Agents Alkylating Glycoproteins education.field_of_study Leptin receptor biology Brain Neoplasms SOXB1 Transcription Factors Cell Biology nervous system diseases Dacarbazine Drug Resistance Neoplasm biology.protein Cancer research Neoplastic Stem Cells Receptors Leptin Signal transduction Glioblastoma Peptides Octamer Transcription Factor-3 Developmental Biology medicine.drug Signal Transduction |
| Popis: | Glioblastoma is a highly aggressive malignant disease with notable resistance to chemotherapy. In this study, we found that leptin receptor (ObR)-positive glioblastoma cells were resistant to temozolomide (TMZ), and TMZ-resistant cells exhibited high expression of ObR. ObR can serve as a marker to enrich glioblastoma cells with some stem/progenitor cell traits, which explained the reason for TMZ resistance of ObR+ cells. STAT3-mediated SOX2/OCT4 signaling axis maintained the stem/progenitor cell properties of ObR+ cells, which indirectly regulated glioblastoma TMZ resistance. These findings gain insight into the molecular link between obesity and glioblastoma, and better understanding of this drug-resistant population may lead to the development of more effective therapeutic interventions for glioblastoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|