Calibrator material selection: a key criteria during biomarker assay method development
| Autor: | Timothy V Olah, Yan Zhang, Rong Liu, Jon E. Peterson, Rasa Santockyte, Sai P Thankamony |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Computer science
010401 analytical chemistry Clinical Biochemistry Context (language use) General Medicine 030226 pharmacology & pharmacy 01 natural sciences Method development 0104 chemical sciences Analytical Chemistry 03 medical and health sciences Medical Laboratory Technology Biomarker 0302 clinical medicine Material selection Risk analysis (engineering) Calibration Lc ms ms Key (cryptography) Humans Biological Assay General Pharmacology Toxicology and Pharmaceutics Biomarkers Selection (genetic algorithm) |
| Zdroj: | Bioanalysis. 13:787-796 |
| ISSN: | 1757-6199 1757-6180 |
| DOI: | 10.4155/bio-2020-0208 |
| Popis: | Biomarker assay method development is a multistep rigorous process and calibrant material selection is integral to ensuring the quality of such assays. However, the impact of selection of calibrator material may often get overlooked. In this article, we highlight three case studies where biomarker calibrant material selection was deemed an essential criterion for consideration. Through these case studies we highlight challenges faced, steps taken and discuss the impact on assay-related decision-making. We also provide additional perspectives for selection and characterization of calibrant proteins in the setting of an evolving biomarker context of use. |
| Databáze: | OpenAIRE |
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