Effect of Oral Administration of β-D-glucan from Aureobasidium pullulans ADK-34 on Candida and MRSA Infections in Immunosuppressed Mice
| Autor: | Asuka, Tanioka, Kazumi, Hayama, Masayasu, Mitsuya, Shigeru, Tansho, Yasuo, Ono, Kazufumi, Tsubaki, Shigeru, Abe |
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| Rok vydání: | 2012 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
beta-Glucans Cyclophosphamide medicine.medical_treatment Administration Oral C. albicans medicine.disease_cause Microbiology Beta-glucan Immunocompromised Host Mice chemistry.chemical_compound Ascomycota Life Prolongation Weight Loss medicine Animals Immunosuppression Therapy business.industry Candidiasis Immunosuppression Staphylococcal Infections Methicillin-resistant Staphylococcus aureus Life Support Care Infectious Diseases chemistry business medicine.drug |
| Zdroj: | Medical Mycology Journal. 53:41-48 |
| ISSN: | 2186-165X 2185-6486 |
| DOI: | 10.3314/mmj.53.41 |
| Popis: | We examined the effect of the oral administration of β-D-glucan derived from Aureobasidium pullulans ADK-34 (AP-FBG) on Candida albicans or methicillin-resistant Staphylococcus aureus (MRSA) infection in immunosuppressed mice. Mice pretreated with cyclophosphamide (CY) were intraperitoneally administered AP-FBG for 4 days and then infected with 6×10(4) C. albicans cells. In a preliminary experiment, the survival time of the Candida-infected mice treated with AP-FBG was clearly prolonged. Similarly, the effect of the oral administration of AP-FBG was examined. Mice were orally given 2.5% AP-FBG in feed for 42 days from 14 days prior to 2×10(4) C. albicans cells infection. The survival time of mice treated with AP-FBG was significantly prolonged and the viable cell count in the kidneys of the survivors was significantly decreased at 30 days after infection. The effects of the oral administration of AP-FBG on intestinal MRSA infection were also examined. Mice were given 2.5% AP-FBG orally in feed for 30 days before and after oral MRSA infection and treated with CY 12 days after the infection. The number of viable MRSA cells or the IgA production in feces did not significantly change, while AP-FBG administration seemed to relieve temporally the loss of body weight of mice.These results suggest that oral pre-administration of AP-FBG promoted resistance of CY-treated mice to C. albicans and lessened the weight reduction of CY-mice infected by MRSA. |
| Databáze: | OpenAIRE |
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