Large Transmission Clusters of HIV-1 Main Genotypes Among HIV-1 Individuals Before Antiretroviral Therapy in the Hebei Province, China
| Autor: | Meng Liu, Ning An, Xinli Lu, Yan Li, Yingying Wang, Lin Ma, Junjuan Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male China Adolescent Genotype Sexual Behavior Immunology Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Men who have sex with men law.invention 03 medical and health sciences Sexual and Gender Minorities Young Adult 0302 clinical medicine Beijing law Virology Antiretroviral Therapy Highly Active Drug Resistance Viral medicine Floating population Humans 030212 general & internal medicine Epidemics Heterosexuality Phylogeny virus diseases Sequence Analysis DNA Middle Aged Antiretroviral therapy 030104 developmental biology Infectious Diseases Transmission (mechanics) Cross-Sectional Studies HIV-1 Female Demography |
| Zdroj: | AIDS research and human retroviruses. 36(5) |
| ISSN: | 1931-8405 |
| Popis: | In recent 10 years, the sexual contact transmission has led to the consecutive upsurge of HIV in Hebei. Especially, the risk behaviors such as homosexual contact in Hebei have presented challenges for HIV prevention and treatment efforts. In this study, we found that 98.9% of subjects attributed their HIV-1 infections to sexual contact, and men who have sex with men (MSM) accounted for 77.5%. CRF01_AE (49.6%), CRF07_BC (29.7%), and subtype B (13.0%) were three main genotypes. AE_cluster 1 (73 cases), AE_cluster 2 (62 cases), and 1 large 07_BC cluster (75 cases) were identified, and only closely clustered with MSM sequences from Beijing. Further, all of HIV-1-resistant strains were circulating in transmission clusters. Particularly, 76.5% of subjects resistant to drugs were circulating in above three large transmission clusters associated with MSM from Beijing. Our study proved that the busy movement of MSM between Beijing and Hebei could meet conveniently, which might result in the bidirectional exchange of HIV-1 strains between Beijing and Hebei. As the most frequent genotypes, large transmission clusters associated with CRF01_AE and CRF07_BC have become one of the main factors resulting in the rapid increase of HIV in Hebei. Therefore, the enhanced surveillance for HIV should be planned early among the floating population traveling between Beijing and Hebei. Hebei should construct the cooperative mechanism for HIV prevention and control together with Beijing. |
| Databáze: | OpenAIRE |
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