Diastolic left ventricular function in relation to the retinal microvascular fractal dimension in a Flemish population

Autor: Jesus D. Melgarejo, Lutgarde Thijs, Harry A.J. Struijker-Boudier, Yugang Dong, Nicholas Cauwenberghs, Jan A. Staessen, Peter Verhamme, Zhenyu Zhang, Tatiana Kuznetsova, Fang-Fei Wei, Chen Liu
Přispěvatelé: RS: Carim - H03 ECM and Wnt signaling, Farmacologie en Toxicologie
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
fractal dimension
medicine.medical_specialty
Retinal microcirculation
Left ventricular diastolic function
Physiology
Population
Diastole
Hypertensive Retinopathy
030204 cardiovascular system & hematology
Fractal dimension
Article
Ventricular Function
Left
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Belgium
population science
Internal medicine
Internal Medicine
Medicine
Humans
030212 general & internal medicine
education
education.field_of_study
Science & Technology
Ventricular function
business.industry
Hazard ratio
Retinal
Middle Aged
Fractal analysis
Confidence interval
retinal microcirculation
Fractals
chemistry
Peripheral Vascular Disease
Echocardiography
Cardiology
Cardiovascular System & Cardiology
Population science
Female
Cardiology and Cardiovascular Medicine
business
Life Sciences & Biomedicine
Zdroj: Hypertension Research, 44(4), 446-453. Nature Publishing Group
Hypertension Research
ISSN: 0916-9636
Popis: Fractal analysis provides a global assessment of vascular networks (e.g., geometric complexity). We examined the association of diastolic left ventricular (LV) function with the retinal microvascular fractal dimension. A lower fractal dimension signifies a sparser retinal microvascular network. In 628 randomly recruited Flemish individuals (51.3% women; mean age, 50.8 years), we measured diastolic LV function by echocardiography and the retinal microvascular fractal dimension by the box-counting method (Singapore I Vessel Assessment software, version 3.6). The left atrial volume index (LAVI), e′, E/e′ and retinal microvascular fractal dimension averaged (±SD) 24.3 ± 6.2 mL/m2, 10.9 ± 3.6 cm/s, 6.96 ± 2.2, and 1.39 ± 0.05, respectively. The LAVI, E, e′ and E/e′ were associated (P 2 (95% confidence interval, −1.98 to −1.01), 2.57 cm/s (1.31–3.84), 1.34 cm/s (1.07–1.60), and −0.74 (−0.91 to −0.57), respectively. With adjustments applied for potential covariables, the associations of E peak and E/e′ with the retinal microvascular fractal dimension remained significant (P ≤ 0.020). Over a median follow-up of 5.3 years, 18 deaths occurred. The crude and adjusted hazard ratios expressing the risk of all-cause mortality associated with a 1-SD increment in the retinal microvascular fractal dimension were 0.36 (0.23–0.57; P P = 0.035), respectively. In the general population, a lower retinal microvascular fractal dimension was associated with greater E/e′, a measure of LV filling pressure. These observations can potentially be translated into new strategies for the prevention of diastolic LV dysfunction.
Databáze: OpenAIRE
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