Efficient Penetration into Aqueous Humor by Administration of Oral and Topical Levofloxacin
| Autor: | Takuya Kataoka, Masaya Ishida, Keiko Niwa, Masahiro Zako, Masayoshi Iwaki |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Ofloxacin medicine.medical_specialty Oral treatment genetic structures medicine.medical_treatment Administration Oral Aqueous humor Cataract Extraction Levofloxacin Postoperative Complications Endophthalmitis Cataracts Ophthalmology medicine Humans Tissue Distribution Pharmacology (medical) Eye surgery Chromatography High Pressure Liquid Aged Aged 80 and over Pharmacology business.industry Reproducibility of Results Drug administration Middle Aged Cataract surgery medicine.disease eye diseases Anti-Bacterial Agents Vitreous Body Anesthesia Female sense organs Ophthalmic Solutions business medicine.drug |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 27:247-250 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.2011.0006 |
| Popis: | Purpose: We investigated whether an optimized combination of oral and topical levofloxacin would lead to higher levofloxacin concentrations in aqueous humor. Methods: Fifteen patients with cataracts in both eyes began topical treatment at 1 week before the first surgery and oral treatment at 1 day before the first surgery. On the day of surgery, they received oral and topical levofloxacin at 4 h and 1 h before surgery, respectively. Two days after the first operation, we performed cataract surgery on the second eye with the same drug administration protocol. Results: Postsurgery concentrations of levofloxacin in the aqueous humor of the first and second eyes were 2.87±0.89 μg/mL (mean±standard deviation, n=15) and 3.76±1.32 μg/mL, respectively; the levofloxacin level in the second eye was significantly higher than that in the first eye (P=0.0085). Conclusions: Our protocol to achieve high aqueous humor concentrations of levofloxacin may be favorable in preventing endophthalmitis after eye surgery. |
| Databáze: | OpenAIRE |
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