Foetal life protein provision of mink (Neovison vison) changes the relative mRNA abundance of some hepatic enzymes regulating fat metabolism

Autor:	Maria Arantzazu Aguinaga Casañas, Connie Frank Matthiesen, Anne-Helene Tauson
Rok vydání:	2014
Předmět:	medicine.medical_specialty Low protein Offspring medicine.medical_treatment Fats Fetus Low-protein diet Internal medicine biology.animal Gene expression Diet Protein-Restricted medicine Animals RNA Messenger Carnitine Mink reproductive and urinary physiology Carnitine O-Palmitoyltransferase General Veterinary biology Nutritional Requirements Lipid metabolism General Medicine Animal Feed Fatty acid synthase Endocrinology Gene Expression Regulation Liver embryonic structures biology.protein Animal Nutritional Physiological Phenomena Female Animal Science and Zoology Dietary Proteins Fatty Acid Synthases Acetyl-CoA Carboxylase medicine.drug
Zdroj:	Archives of Animal Nutrition. 68:159-169
ISSN:	1477-2817 1745-039X
Popis:	The nutrient provision to pregnant females has high impact on the growth and metabolism of their offspring. The objective was to investigate if the expression of hepatic enzymes regulating the fat metabolism was affected in foetuses and adult female mink born by dams fed either a low or an adequate level of protein during late gestation. The relative abundances of acetyl coenzyme A carboxylase (ACC), fatty acid synthase (FAS) and carnitine palmitoyl transferase 1 (CPT1) mRNA were determined by qualitative polymerase chain reaction in the livers of F₀- and F₁-generation dams and in F₁-generation foetuses. Low protein provision during foetal life resulted in a lower expression of FAS in foetal liver but a tendency towards increased expression in the liver of adult dams. There was a tendency towards an effect of life stage of the animal on the expression of ACC resulting in a higher expression among F₁ foetuses exposed to low protein during foetal life than F₀ dams fed a low protein diet during late gestation. The expression of CPT1 was significantly lower among dams exposed to low protein provision during foetal life than controls, possibly indicating a lower rate of mitochondrial β-oxidation. Further investigations are needed to clarify the consequences of these changes for the fat metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d67b4e4f0c4878593408dffead0f8 https://doi.org/10.1080/1745039x.2014.889506 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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