Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids
| Autor: | Pierre Louisot, Eric Vignon, Michel Richard, Pierre Mathieu, J. C. Balblanc |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Knee Joint medicine.medical_treatment Biomedical Engineering Osteoarthritis Phospholipases A Arthritis Rheumatoid Phospholipase A2 Rheumatology Internal medicine Synovial Fluid medicine Humans Synovial fluid Orthopedics and Sports Medicine Collagenases Prospective Studies Interleukin 6 Aged Metalloproteinase biology Interleukin-6 Tumor Necrosis Factor-alpha Chemistry Osmolar Concentration Metalloendopeptidases Middle Aged medicine.disease Phospholipases A2 Endocrinology Cytokine Rheumatoid arthritis Immunology biology.protein Collagenase Cytokines Female Matrix Metalloproteinase 3 Interleukin-1 medicine.drug |
| Zdroj: | Osteoarthritis and Cartilage. 1:115-120 |
| ISSN: | 1063-4584 |
| Popis: | Collagenase, stromelysin and phospholipase A2 (PLA2) activity as well as interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) concentration were determined in the knee joint synovial fluid (SF) of 26 patients with osteoarthritis (OA) and with rheumatoid arthritis (RA). Collagenase and stromelysin were detected in 80.7 and 69.2% of OA SF, respectively. When present, the mean activity of both enzymes was approximately two times lower in OA than in RA SF. PLA2 activity was present in all SF with no significant difference between OA and RA SF. IL-1 beta, TNF alpha and IL-6 were found in 0, 96.1 and 84.6% of OA SF, respectively. Mean TNF alpha and IL-6 concentration was also lower in OA than in RA SF. Metalloprotease activity correlated weakly with IL-6 level and enzymatic activities were unrelated with TNF alpha in OA SF. |
| Databáze: | OpenAIRE |
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