Telomerase Activity In Preleukemia And Acute Myelogenous Leukemia

Autor:	Azra Raza, Biaoru Li, Harpreet Chopra, Ray Win Huang, Harvey D. Preisler, Paul Toofanfard, Jie Yang, Erzsebet Horvath, Colleen B. Andrews, Yi Xin Chen
Rok vydání:	2000
Předmět:	Adult Male Cancer Research Telomerase Adolescent Preleukemia Myelogenous Bone Marrow hemic and lymphatic diseases medicine Humans Telomerase reverse transcriptase Aged Aged 80 and over Acute leukemia business.industry Hematology Middle Aged medicine.disease Telomere Enzyme Activation Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology Immunology Female Bone marrow business Precancerous Conditions Cell Division
Zdroj:	Leukemia & Lymphoma. 36:579-587
ISSN:	1029-2403 1042-8194
Popis:	The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00be70825fbefcd39960b7aaced5da2 https://doi.org/10.3109/10428190009148406 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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