miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
| Autor: | Shuqian He, Qing Sun, He Dong, Maoqiang Ma, Guihui Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty FGF2 Fibroblast growth factor OncoTargets and Therapy Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Cancer stem cell Internal medicine Medicine Pharmacology (medical) Growth factor receptor inhibitor skin and connective tissue diseases Original Research Gene knockdown business.industry miR-203 medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis business Transforming growth factor |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Shuqian He, Guihui Zhang, He Dong, Maoqiang Ma, Qing Sun Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China Abstract: Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer. Keywords: breast cancer, miR-203, FGF2 |
| Databáze: | OpenAIRE |
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