The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer
| Autor: | Shreya Narayanan, Luis Pena, Mark Friedman, Ashok Shiani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Hepatitis C virus Autoimmune hepatitis Review medicine.disease_cause Chronic liver disease Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Primary biliary cirrhosis Risk Factors Internal medicine and cirrhosis medicine Humans Neoplasm Staging Hepatitis B virus business.industry Liver Neoplasms Hematology General Medicine hepatocellular carcinoma medicine.disease Prognosis digestive system diseases Oncology 030220 oncology & carcinogenesis Hereditary hemochromatosis Hepatocellular carcinoma 030211 gastroenterology & hepatology Female business liver disease |
| Zdroj: | Cancer Control : Journal of the Moffitt Cancer Center |
| ISSN: | 1526-2359 |
| Popis: | Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Underlying chronic liver disease has been associated with an increased risk of developing HCC. This study is a review of the current literature regarding the diagnosis, prognostic significance, and role of treating underlying liver disease in patients who are at risk of primary liver cancer. Relevant peer review of the English literature between 1980 and 2017 within PubMed and the Cochrane library was conducted for scientific content on current advances in managing chronic liver diseases and the development of hepatocellular carcinoma. Hepatitis C virus, hepatitis B virus (HBV), nonalcoholic steatohepatitis, autoimmune hepatitis, hereditary hemochromatosis, Wilson disease, primary biliary cirrhosis, α 1-antitrypsin deficiency, and certain drugs lead to an increased risk of developing HCC. Patients with underlying liver disease have an increased incidence of HCC. Hepatitis C virus, HBV, and hemochromatosis can directly lead to HCC without the presence of cirrhosis, while HCC related to other underlying liver diseases occurs in patients with cirrhosis. Treating the underlying liver disease and reducing the progression to cirrhosis should lead to a decreased incidence of HCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|