| Autor: |
Matti Mauramo, Suvi-Tuuli Vilen, Timo Sorsa, Tuula Salo |
| Přispěvatelé: |
Department of Pathology, HUSLAB, HUS Helsinki and Uusimaa Hospital District, Department of Oral and Maxillofacial Diseases, HUS Head and Neck Center |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Dental Oral Biology and Craniofacial Research. :1-8 |
| ISSN: |
2613-4950 |
| DOI: |
10.31487/j.dobcr.2020.06.05 |
| Popis: |
Enamel matrix derivative (EMD) can enhance proliferation and migration of different oral cell lines, including malignant oral carcinoma cells, in vitro and in vivo. The composition of EMD is not known, but part of the effects have been postulated to be caused by transforming growth factor-beta-1 (TGF-beta 1). This study aimed to compare target genes of EMD and TGF-beta 1 on highly malignant oral carcinoma HSC-3 cells. Microarrays were used to examine differentially expressed genes in HSC-3 cells after 6h and 24h incubations with EMD (200 µg/ml) or TGF-beta 1 (10 ng/ml). Gene Ontology (GO) enrichment analysis of the regulated genes was also conducted. After 6h and 24h of EMD treatments 42 and 12 genes, respectively, were statistically significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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