The Use of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker in Chronic Obstructive Pulmonary Disease Exacerbations: A Literature Review Update
| Autor: | Nikolaos-Dimitrios Pantzaris, Aikaterini Psaromyalou, Ioanna Koniari, Dimitrios Velissaris, Diamantina-Xanthi Spilioti |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pulmonary disease Review Procalcitonin COPD exacerbation 03 medical and health sciences 0302 clinical medicine Antibiotic therapy medicine COPD Prognostic biomarker In patient 030212 general & internal medicine Major complication Intensive care medicine AECOPD business.industry Chronic obstructive pulmonary disease fungi food and beverages General Medicine medicine.disease 030228 respiratory system Biomarker (medicine) PCT business |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr3458w |
| Popis: | Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication in COPD patients which can be triggered by bacterial or viral infections, environmental pollutants and other causes. Procalcitonin (PCT), a peptide that markedly increases in cases of bacterial infection, has been extensively investigated as a biomarker in the diagnosis, prognosis and treatment in patients with AECOPD. A number of studies published in the last decade, tried to investigate whether PCT levels can differentiate between bacterial and other causes of exacerbations, if they can be used as a guide for optimal antibiotic therapy and if they can be a tool in the assessment of the severity and the need for further interventions in the management of those patients. This review aims to gather, summarize and critically present all the available data to date. |
| Databáze: | OpenAIRE |
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