Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
| Autor: | Hartmut Goldschmidt, Volker Schirrmacher, Carmen Choi, Andreas Trojan, Nora Sommerfeldt, Mathias Witzens, Anthony D. Ho, Marianna Bucur, Markus Feuerer, Philipp Beckhove |
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| Rok vydání: | 2004 |
| Předmět: |
Immunology
T-Cell Antigen Receptor Specificity CD8-Positive T-Lymphocytes Lymphocyte Activation Biochemistry Antigen Antigens Neoplasm Bone Marrow HLA-A2 Antigen medicine Cytotoxic T cell Humans Amino Acid Sequence Perforin production Antigens MUC1 Multiple myeloma Glycoproteins Blood Cells business.industry Mucin-1 Mucins Cell Biology Hematology T lymphocyte medicine.disease Peptide Fragments medicine.anatomical_structure Case-Control Studies Bone marrow business Multiple Myeloma Immunologic Memory CD8 |
| Zdroj: | Blood. 105(5) |
| ISSN: | 0006-4971 |
| Popis: | Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detected on a majority of multiple myeloma cell lines. We analyzed bone marrow and peripheral blood of 68 patients with HLA-A2–positive myeloma for the presence and functional activity of CD8 T cells specific for the MUC1-derived peptide LLLLTVLTV. Forty-four percent of the patients with MM contained elevated frequencies of MUC1-specific CD8 T cells in freshly isolated samples from peripheral blood (PB) or bone marrow (BM) compared with corresponding samples from healthy donors. BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon γ (IFN-γ) secretion, perforin production, and cytotoxicity. |
| Databáze: | OpenAIRE |
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