Urinary gonadotropin peptide: collection of specimens and cutoff levels
| Autor: | Maria Marchetti, Mario Plebani, Francesca Lazzari, Lucio Bacelle, Filippo Navaglia, Simonetta Polonio |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Adolescent Urinary system Clinical Biochemistry Urine Sensitivity and Specificity Human chorionic gonadotropin Urine collection device Specimen Handling Excretion chemistry.chemical_compound Pregnancy Internal medicine medicine Biomarkers Tumor Immunology and Allergy Humans Chorionic Gonadotropin beta Subunit Human Circadian rhythm Morning Aged Creatinine business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Hematology Middle Aged Peptide Fragments Circadian Rhythm Postmenopause Medical Laboratory Technology Endocrinology chemistry Premenopause Female business Genital Diseases Female |
| Popis: | A low-molecular-weight form of human chorionic gonadotropin (hCG), urinary gonadotropin peptide (UGP), has been isolated from the urine of pregnant women and of patients with cancer, mainly of gynecological origin. The clinical value of UGP measurement in gynecological diseases is under investigation but a preliminary study is necessary in order to ascertain whether there is a circadian rhythm in UGP production, to clarify the best way to express the results, and to establish the cutoff and decisional values. In our work we demonstrated a significant correlation between the UGP output and the UGP excretion normalized for urinary creatinine. A very significant agreement was even found in 24-hr urine collections and UGP concentration of a single morning specimen from the same patients. No evident circadian rhythm was found, although some patients presented morning levels of UGP higher than in other collections. UGP postmenopausal levels were higher than premenopausal. The cutoff level, adopting the 95.0 percentile, was 200 pmol/mol creatinine. |
| Databáze: | OpenAIRE |
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