Inter-species variation of schistosome 28-kDa glutathione S-transferases
| Autor: | Jean-Pierre Lecocq, C. Godin, Raymond J. Pierce, Bertrand Sellin, André Capron, François Trottein, Maria De Lourdes Sampaio Silva, Isabelle Gorillot, Martin G. Taylor |
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| Rok vydání: | 1992 |
| Předmět: |
Molecular Sequence Data
Epitope Microbiology Antigen Species Specificity Sequence Homology Nucleic Acid parasitic diseases Antigenic variation Animals Humans Amino Acid Sequence Cloning Molecular Molecular Biology Schistosoma Glutathione Transferase Schistosoma haematobium Vaccines biology Base Sequence Schistosoma japonicum Genetic Variation biology.organism_classification Molecular biology Parasitology Schistosoma mansoni Trematoda |
| Zdroj: | Molecular and biochemical parasitology. 54(1) |
| ISSN: | 0166-6851 |
| Popis: | The 28-kDa glutathione S-transferase from Schistosoma mansoni (Sm28GST) is a candidate vaccine antigen. To evaluate the antigenic and phylogenetic variations between the 28-kDa GSTs from 4 species of schistosome, we have cloned and sequenced the 28-kDa GSTs from Schistosoma haematobium (Sh28GST) and Schistosoma bovis (Sb28GST). Sb28GST and Sh28GST are more similar to each other (97%) than to Sm28GST (90%) and particularly to the 28-kDa GST from Schistosoma japonicum (Sj28GST, 77%). Antisera directed against the major Sm28GST epitopes revealed differences in the recognition of the 28-kDa GSTs from the other schistosome species suggesting that these regions have been subjected to evolutionary pressure. The consequences of such species-specific epitopes on the development of a multi-species anti-schistosome vaccine are discussed. |
| Databáze: | OpenAIRE |
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