Human Leukocyte Antigens Class II Alleles Affecting the Response to 5–7 Year Antiretroviral Therapy in A Latvian Cohort
| Autor: | Baiba Rozentāle, Inga Ažiņa, Ksenija Kramiča, Aleksandrs Koļesovs, Oksana Koļesova, Vladislavs Jasinskis, Jeļena Eglīte, Ludmila Vīksna |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Class (computer programming) Multidisciplinary General interest Science Latvian hiv-1 Human leukocyte antigen hla class ii Antiretroviral therapy language.human_language 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immunology Cohort language Allele cd4+ t cells 030217 neurology & neurosurgery art |
| Zdroj: | Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 73, Iss 2, Pp 84-88 (2019) |
| Popis: | Antiretroviral therapy (ART) aims at suppressing viral replication and strengthening immune system in patients with HIV-1. Human Leukocyte Antigens (HLA) are among factors responsible for effectiveness of ART. The aim of this study was to determine the effect of HLA Class II alleles on the response to long-time ART, assessed by a change in CD4+ T-cell count in relation to viral load. The sample included 69 patients (17 females and 52 males) aged 20 to 50 with HIV-1 infection, who were undergoing ART in the Latvian Centre of Infectious Diseases. The median period of observation was 5.7 years. CD4+ T-cell count and viral load were analysed at the baseline and end of the period of observation. HLA typing was performed by polymerase chain reaction with low resolution sequence specific primers. Multiple hierarchical linear regression analysis confirmed that an increase in HIV-1 viral load was associated with a decrease in the level of CD4+ T-cell count. In addition, HLA-DRB1*04 and HLA-DQB1*06:01 alleles contributed negatively to the level of CD4+ T-cell count. |
| Databáze: | OpenAIRE |
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