Proximal tubular function in dogs with thoracic caval constriction
| Autor: | R. B. Auld, Norman G. Levinsky, Edward A. Alexander |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
medicine.medical_specialty Sodium Kidney Glomerulus Natriuresis chemistry.chemical_element Blood Pressure Vena Cava Inferior Punctures Nephron Sodium Chloride Constriction Dogs Internal medicine medicine Animals cardiovascular diseases Aminohippuric acid Kidney Dehydration Renal sodium reabsorption Reabsorption Chemistry Aminohippuric Acids Inulin Ascites Articles General Medicine Thorax Water-Electrolyte Balance Stimulation Chemical Kidney Tubules Endocrinology medicine.anatomical_structure Depression Chemical cardiovascular system Female Isotonic Solutions Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Clinical Investigation. 50:2150-2158 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci106709 |
| Popis: | The effect of saline infusion on proximal sodium reabsorption was compared in normal dogs and in dogs with acute or chronic partial thoracic vena cava obstruction. After acute vena cava obstruction, proximal fractional sodium reabsorption rose by 74%. During continued caval obstruction, saline loading strikingly reduced proximal reabsorption but sodium excretion remained minimal. In chronic caval dogs, saline loading reduced proximal fractional sodium reabsorption by 31% but sodium excretion in the micropunctured kidney was only 41 muEq/min. After saline infusion in normal dogs, proximal fractional sodium reabsorption fell 39% while unilateral sodium excretion rose to 584 muEq/min. Nephron filtration rate was also measured before and after saline loading in normal and chronic caval dogs in both repunctured and fresh tubules. There was a marked increase in nephron filtration rate in repunctured tubules and no change in freshly punctured tubules in both groups. The effect of saline loading on nephron filtration rate in normal and chronic caval dogs was similar, therefore, whether repunctured or fresh nephrons were considered.We conclude that saline infusion depresses proximal sodium reabsorption in acute and chronic TVC dogs. Since saline loading markedly increases distal delivery without a concomitant natriuresis, enhanced distal reabsorption must play a major role in the sodium retention exhibited by chronic caval dogs. Redistribution of filtrate does not appear to be a factor in this sodium retention. |
| Databáze: | OpenAIRE |
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