Current Understanding of Molecular Phase Separation in Chromosomes
| Autor: | Je-Kyung Ryu, Jeong-Mo Choi, Da-Eun Hwang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chromosomes
Study phase Current (mathematics) QH301-705.5 Macromolecular Substances cohesin Review biomolecular phase separation multivalent DNA-binding proteins macromolecular substances Intrinsically disordered proteins Phase Transition Catalysis Inorganic Chemistry bridging-induced phase separation Chromosomes Human Humans Chromosome Structures stickers-and-spacers framework Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Cohesin Chemistry Organic Chemistry General Medicine Computer Science Applications compartments Chemical physics intrinsically disordered proteins |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 10736, p 10736 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms221910736 |
| Popis: | Biomolecular phase separation denotes the demixing of a specific set of intracellular components without membrane encapsulation. Recent studies have found that biomolecular phase separation is involved in a wide range of cellular processes. In particular, phase separation is involved in the formation and regulation of chromosome structures at various levels. Here, we review the current understanding of biomolecular phase separation related to chromosomes. First, we discuss the fundamental principles of phase separation and introduce several examples of nuclear/chromosomal biomolecular assemblies formed by phase separation. We also briefly explain the experimental and computational methods used to study phase separation in chromosomes. Finally, we discuss a recent phase separation model, termed bridging-induced phase separation (BIPS), which can explain the formation of local chromosome structures. |
| Databáze: | OpenAIRE |
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