Exhaustive exercise decreases renal organic anion transporter 3 function
| Autor: | Rattikarn Noitem, Varanuj Chatsudthipong, Chaowalit Yuajit, Tipwadee Bunprajun |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell physiology Male medicine.medical_specialty Kidney Cortex Organic anion transporter 1 Physiology Estrone Endogeny Organic Anion Transporters Sodium-Independent 03 medical and health sciences 0302 clinical medicine Internal medicine Physical Conditioning Animal medicine Animals Secretion Rats Wistar Ion Transport biology Chemistry Transporter Biological Transport Plasma levels Rats 030104 developmental biology Endocrinology Organic anion transport biology.protein 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | The journal of physiological sciences : JPS. 69(2) |
| ISSN: | 1880-6562 |
| Popis: | This study aimed to investigate the effects of various types of exercise on organic anion transporter 3 (Oat3) function, a major transporter that plays a role in the secretion of a variety of drugs and endogenous compounds. Male Wistar rats were randomly allocated to non-exercise, exhaustive, acute and training exercise groups. The function of Oat3 was assessed by the uptake of [3H]-estrone sulfate ([3H]-ES) into rat renal cortical slices. Acute and training exercises had no effect on [3H]-ES uptake whereas a marked reduction in [3H]-ES uptake occurred immediately after exhaustive exercise. However, the reduction in Oat3 function was gradually recovered at 6 and 24 h after the exercise session. Importantly, the impairment of Oat3 function was associated with a decrease in renal Oat3 protein expression. Our results indicate that exhaustive exercise produces a significant impact on renal organic anion transport function, which in turn could alter the plasma level of drugs and compounds in the body. |
| Databáze: | OpenAIRE |
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