Quantitative longitudinal evaluation of diaschisis-related cerebellar perfusion and diffusion parameters in patients with supratentorial hemispheric high-grade gliomas after surgery
| Autor: | Matthew A. Scoggins, Robert J. Ogg, Zoltan Patay, Arun George, Harris Hawk, Carlos Parra, Alberto Broniscer, Yimei Li |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Hemodynamics Magnetic resonance angiography Young Adult Cerebellum Fractional anisotropy medicine Humans Longitudinal Studies Postoperative Period Child Diaschisis Clinical Trials as Topic medicine.diagnostic_test business.industry Supratentorial Neoplasms Magnetic resonance imaging Glioma Magnetic Resonance Imaging Surgery Diffusion Tensor Imaging Neurology Cerebral blood flow Cerebrovascular Circulation Anisotropy Female Neurology (clinical) Neoplasm Grading Psychology Nuclear medicine business Perfusion Magnetic Resonance Angiography Diffusion MRI Follow-Up Studies |
| Zdroj: | Cerebellum (London, England). 13(5) |
| ISSN: | 1473-4230 |
| Popis: | Decreased cerebral blood volume (CBV) in contralateral cerebellar gray matter (cGM) in conjunction with cerebellar white matter (cWM) damage, consistent with crossed cerebro-cerebellar diaschisis (cCCD) develop following supratentorial hemispheric stroke. In this study, we investigated the longitudinal evolution of diaschisis-related cerebellar perfusion and diffusion tensor-imaging (DTI) changes in patients after surgery for supratentorial brain tumors. Eight patients (M:F 5:3, age 8–22 years) who received surgery for supratentorial high-grade gliomas were evaluated. Initial MRI studies were performed 19–54 days postoperatively, with follow-ups at 2- to 3-month intervals. For each study, parametric maps of the cerebellum were generated and coregistered to T1-weighted images that had been previously segmented for cGM and cWM. Aggregate mean values of CBV, cerebral blood flow (CBF), and fractional anisotropy (FA) were obtained separately for cGM and cWM, and asymmetry indices (AIs) were calculated. Hemodynamic changes were more robust in cGM than in cWM. Seven patients showed decreased perfusion within cGM contralateral to the supratentorial lesion on the first postoperative study, and asymmetry was significant for both CBV (p = 0.008) and CBF (p |
| Databáze: | OpenAIRE |
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