Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent
| Autor: | Mu Yang, Ulrich Bierbach, Ravi Singh, Xiyuan Yao, Michael D. Gross, Ye Zheng, Cale D. Fahrenholtz, Brian W. Bernish, Song Ding, George L. Donati, Mariah Wright |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antineoplastic Agents
Breast Neoplasms 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Biochemistry Article Inorganic Chemistry Drug Delivery Systems Breast cancer Cell Line Tumor medicine Humans Cytotoxicity Triple-negative breast cancer Platinum Nanotubes Carbon Chemistry Hyperthermia Induced Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Apoptosis Drug delivery Cancer cell Cancer research Acridines Female 0210 nano-technology Drug carrier |
| Zdroj: | Journal of Inorganic Biochemistry. 165:170-180 |
| ISSN: | 0162-0134 |
| Popis: | A three-component drug-delivery system has been developed consisting of multi-walled carbon nanotubes (MWCNTs) coated with a non-classical platinum chemotherapeutic agent ([PtCl(NH3)2(L)]Cl (P3A1; L = N-(2-(acridin-9-ylamino)ethyl)-N-methylproprionimidamide) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (DSPE-mPEG). The optimized P3A1-MWCNTs are colloidally stable in physiological solution and deliver more P3A1 into breast cancer cells than treatment with the free drug. Furthermore, P3A1-MWCNTs are cytotoxic to several cell models of breast cancer and induce S-phase cell cycle arrest and non-apoptotic cell death in breast cancer cells. By contrast, free P3A1 induces apoptosis and allows progression to G2/M phase. Photothermal activation of P3A1-MWCNTs to generate mild hyperthermia potentiates their cytotoxicity. These findings suggest that delivery of P3A1 to cancer cells using MWCNTs as a drug carrier may be beneficial for combination cancer chemotherapy and photothermal therapy. |
| Databáze: | OpenAIRE |
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