A Convenient One-Pot Aza-Annulation of Primary Amines, Acryloyl Chloride and Electron-Deficient Allenes

Autor:	Philip J. Gray, Whitehead Andrew Jonathan, William B. Motherwell
Rok vydání:	2007
Předmět:	Annulation chemistry.chemical_compound Primary (chemistry) Tandem Chemistry Amide Organic Chemistry Organic chemistry Regioselectivity General Medicine Acryloyl chloride Combinatorial chemistry
Zdroj:	Synlett. 2007:0431-0434
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-2007-967955
Popis:	The selection of electron-deficient allenes as substrates for highly regioselective vinylogous amide formation leads to a convenient one-pot [3+3] annulation sequence for the construction of highly functionalized cyclic enamides. By the selection of the appropriate amines, tandem bicyclisations were achieved, thereby allowing facile access to azabicyclo[4.3.0] systems known to be useful precursors to the biologically important indolozine alkaloids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff75b91259def00b030abaaf0b569ba https://doi.org/10.1055/s-2007-967955 Zobrazit plný text záznamu