Prevalence of production of virus-specific interferon-gamma among seronegative hepatitis C-resistant subjects reporting injection drug use
| Autor: | Stuart Gilmour, Anthony J. Freeman, George Marinos, Peter A. White, Ingrid van Beek, Charles E. Harvey, Rosemary A. Ffrench, Andrew R. Lloyd, William D. Rawlinson, Jeffrey J. Post |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Adolescent Hepatitis C virus Immunoblotting Viral Nonstructural Proteins medicine.disease_cause Virus Interferon-gamma Interferon Risk Factors medicine Immunology and Allergy Humans Interferon gamma Seroconversion Substance Abuse Intravenous Subclinical infection Hepatitis business.industry Reverse Transcriptase Polymerase Chain Reaction Hepatitis C Hepatitis C Antibodies medicine.disease Virology Immunity Innate Infectious Diseases Immunology Leukocytes Mononuclear RNA Viral Female business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 190(6) |
| ISSN: | 0022-1899 |
| Popis: | This report describes subjects who were highly likely to have been repeatedly exposed to hepatitis C virus (HCV) through injection drug use and who remained negative for anti-HCV antibody. Production of virus-specific interferon- gamma by peripheral blood mononuclear cells was seen in the majority of subjects (72%) and was associated with higher-risk behavior. For 92% of the subjects, results of recombinant immunoblot assays demonstrated faint bands against nonstructural proteins. The immune responses described are likely to have been primed and maintained by episodes of subclinical infection without classic seroconversion and may indicate a hepatitis C-resistant phenotype. Vaccine strategies to mimic this response may provide protection against persistent HCV infection. |
| Databáze: | OpenAIRE |
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