Cerebral white matter deficiencies in pedophilic men
| Autor: | Michael E. Kuban, David J. Mikulis, Noor Jehan Kabani, M. Katherine Hanratty, Howard E. Barbaree, Philip E. Klassen, Robert B. Zipursky, James M. Cantor, Ray Blanchard, Blake A. Richards, Thomas Blak, Bruce K. Christensen, Robert Dickey |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Adolescent Sexual Behavior Poison control Grey matter Developmental psychology White matter Parietal Lobe Fasciculus Erotica medicine Humans Arcuate fasciculus Child Pedophilia Biological Psychiatry Anthropometry biology Arcuate Nucleus of Hypothalamus Child Abuse Sexual biology.organism_classification Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health medicine.anatomical_structure nervous system Sexual abuse Sex offense Psychology Penis Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 42:167-183 |
| ISSN: | 0022-3956 |
| Popis: | The present investigation sought to identify which brain regions distinguish pedophilic from nonpedophilic men, using unbiased, automated analyses of the whole brain. T1-weighted magnetic resonance images (MRIs) were acquired from men who demonstrated illegal or clinically significant sexual behaviors or interests (n = 65) and from men who had histories of nonsexual offenses but no sexual offenses (n = 62). Sexual interest in children was assessed by participants' admissions of pedophilic interest, histories of committing sexual offenses against children, and psychophysiological responses in the laboratory to erotic stimuli depicting children or adults. Automated parcellation of the MRIs revealed significant negative associations between pedophilia and white matter volumes of the temporal and parietal lobes bilaterally. Voxel-based morphometry corroborated the associations and indicated that the regions of lower white matter volumes followed, and were limited to, two major fiber bundles: the superior fronto-occipital fasciculus and the right arcuate fasciculus. No significant differences were found in grey matter or in cerebrospinal fluid (CSF). Because the superior fronto-occipital and arcuate fasciculi connect the cortical regions that respond to sexual cues, these results suggest (1) that those cortical regions operate as a network for recognizing sexually relevant stimuli and (2) that pedophilia results from a partial disconnection within that network. Language: en |
| Databáze: | OpenAIRE |
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