8-Aryl xanthines potent inhibitors of phosphodiesterase 5

Autor:	Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
Rok vydání:	2002
Předmět:	Models Molecular Phosphodiesterase Inhibitors Clinical Biochemistry Pharmaceutical Science Biochemistry Isozyme Chemical synthesis chemistry.chemical_compound Drug Discovery medicine Molecular Biology chemistry.chemical_classification Molecular Structure biology Phosphoric Diester Hydrolases Chemistry Organic Chemistry Sulfonamide (medicine) Xanthine In vitro Enzyme Enzyme inhibitor Xanthines cGMP-specific phosphodiesterase type 5 biology.protein Molecular Medicine medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
ISSN:	0960-894X
Popis:	In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff42050bb668b5c21bf1217c7c6b8ce https://doi.org/10.1016/s0960-894x(02)00480-8 Zobrazit plný text záznamu Full Text from ScienceDirect