Synthesis and Biodistribution of 8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine
| Autor: | Mathew T. Martin-Iverson, Sanjay K. Sharma, Alummoottil V. Joshua, John R. Scott, Alexander J.B. McEwan, Douglas N. Abrams, Alicia Strelkov, Peter H. Silverstone |
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| Rok vydání: | 2007 |
| Předmět: |
Biodistribution
Stereochemistry Ligand Receptors Dopamine D4 Organic Chemistry Clinical Biochemistry Brain Pharmaceutical Science General Medicine Biochemistry Chemical synthesis Mice chemistry.chemical_compound Diazepine chemistry Drug Discovery Animals Molecular Medicine Tissue Distribution heterocyclic compounds Rabbits Clozapine Molecular Biology |
| Zdroj: | ChemInform. 38 |
| ISSN: | 1522-2667 0931-7597 |
| Popis: | 8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D4-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits. |
| Databáze: | OpenAIRE |
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